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Combination with valproate is common, but this increases the risk of lamotrigine-induced severe skin reaction Stevens–Johnson syndrome, and necessitates reduced dosing due to the interaction of these drugs.
Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. [7] They are useful for the prevention of seizures in those with absence seizures , partial seizures , and generalized seizures . [ 7 ]
Among bipolar patients taking anticonvulsants, those on lamotrigine have a better cognitive profile than those on carbamazepine, valproate, topiramate, and zonisamide. [36] Although decreased verbal memory and slowed psychomotor speed are common side effects of lithium use [37] [38] these side effects usually disappear after discontinuation of ...
Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication. Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia
Several studies that followed children exposed to ASMs during pregnancy showed that a number of widely used ones (including lamotrigine and levetiracetam) carried a low risk of adverse neurodevelopmental outcomes (cognitive and behavioral) in children when compared to children born to mothers without epilepsy and children born to mothers taking ...
Valproate – Available in extended release form. This drug can be very irritating to the stomach, especially when taken as a free acid. Liver function and CBC should be monitored. [6] Lamotrigine (aka Lamictal) – FDA approved for bipolar disorder maintenance therapy, not for acute mood problems like depression or mania/hypomania. [7]
Valproate has become a commonly prescribed treatment and effectively treats manic episodes. [143] Carbamazepine is less effective in preventing relapse than lithium or valproate. [144] [145] Lamotrigine has some efficacy in treating depression, and this benefit is greatest in more severe depression. [146]
Lamotrigine: Lamictal Levetiracetam: Keppra Lithium salts: Camcolit, Eskalith, Lithobid, Sedalit Oxcarbazepine: Trileptal Topiramate: Topamax Sodium valproate [note 1] Convulex, Depakene, Depakine Enteric, Orfiril, Stavzor Divalproex sodium [note 2] Depakote, Epival, Ergenyl Chrono Sodium valproate and valproic acid in 2.3:1 ratio