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Naphthoylindoles: Any compound containing a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any ...
Indole itself triggers the secretion of glucagon-like peptide-1 (GLP-1) in intestinal L cells and acts as a ligand for AhR. [2] Indole can also be metabolized by the liver into indoxyl sulfate , a compound that is toxic in high concentrations and associated with vascular disease and renal dysfunction . [ 2 ]
3-Hydroxy-16-methoxy-2,3-dihydrotabersonine is a terpene indole alkaloid produced by Catharanthus roseus. The metabolite is a substrate for 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase (NMT) which transfers a methyl group to the nitrogen of the indole ring forming desacetoxyvindoline . [ 1 ]
RCS-4 is a potent cannabinoid receptor agonist, with EC 50 values of 146 nM for human CB 1 receptors, and 46 nM for human CB 2 receptors. [2] All methoxyphenyl regioisomers, and N -butyl homologues of RCS-4 and its regioisomers also display potent agonist activities at CB 1 and CB 2 receptors.
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole Harmine is a reversible inhibitor of monoamine oxidase A (RIMA). [17] Harmaline: C 13 H 14 N 2 O; 4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole Harmaline is also a RIMA. [18] Harmalol: C 12 H 12 N 2 O; 1-Methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol. Tetrahydroharmine: C 13 H 16 N 2 O; 1,2,3,4 ...
The Nenitzescu indole synthesis. This reaction was named for its discoverer, Costin Nenițescu, who first reported it in 1929. [1] It can be performed with a number of different combinations of R-groups, which include methyl, methoxy, ethyl, propyl, and H substituents. [2]
Moreover, 3-hydroxymethyl-beta-carboline blocks the sleep-promoting effect of flurazepam in rodents and – by itself – can decrease sleep in a dose-dependent manner. [16] Another derivative, methyl-β-carboline-3-carboxylate, stimulates learning and memory at low doses but can promote anxiety and convulsions at high doses. [15]
6-MeO-THH, or 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a structural isomer of tetrahydroharmine (7-MeO-THH). 6-MeO-THH is mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved), stating that 6-MeO-THH is very similar to the other carbolines. [1]