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Dede Koswara (1971 – January 30, 2016), also known as the "Tree Man", was an Indonesian carpenter with epidermodysplasia verruciformis (EV), a rare disease that causes the human papillomavirus (HPV) to grow uncontrollably, leading to the development of warts resembling tree bark. For most of his life, he was shunned for having an unknown disease.
Removal of the thick carpet of warts and massive horns on his hands; Removal of the smaller warts on his head, torso, and feet; Covering the hands with grafted skin; In all, 96% of the warts were removed. [19] The surgery was documented by the Discovery Channel and TLC in the episode "Treeman: Search for the Cure".
10-year-old Sahana Khatun may be the first female to ever be diagnosed with 'tree-man syndrome', officially know as Epidermodysplasia Verruciformis.
A similar response occurs in pyoderma gangrenosum and Behcet's syndrome, and is referred to as pathergy. [3] Rarely Koebner phenomenon has been reported as a mechanism of acute myeloid leukemia dissemination. [4] Warts and molluscum contagiosum are often listed as causing a Koebner reaction, but this is by direct inoculation of viral particles. [3]
Infusions of immune globulin can reduce the frequency of bacterial infections, and G-CSF or GM-CSF therapy improves blood neutrophil counts. [5]As WHIM syndrome is a molecular disease arising from gain-of-function mutations in CXCR4, preclinical studies identified plerixafor, a specific CXCR4 antagonist, as a potential mechanism-based therapeutic for the disease. [6]
A seborrheic keratosis is a non-cancerous skin tumour that originates from cells, namely keratinocytes, in the outer layer of the skin called the epidermis.Like liver spots, seborrheic keratoses are seen more often as people age.
A range of types of wart have been identified, varying in shape and site affected, as well as the type of human papillomavirus involved. [6] [7] These include: Common wart (verruca vulgaris), [8] a raised wart with a roughened surface, most common on hands, but can grow anywhere on the body. Sometimes known as a Palmer wart or Junior wart.
Florid cutaneous papillomatosis (FCP) is an obligate paraneoplastic syndrome. FCP begins as the sudden onset of numerous cutaneous papillomas that are clinically indistinguishable from viral warts. The papillomas range from 1 to 3 mm in diameter may spread to involve the entire body, including the face.