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The dermatome is the dorsal portion of the paraxial mesoderm somite which gives rise to the skin . In the human embryo, it arises in the third week of embryogenesis. [2] It is formed when a dermomyotome (the remaining part of the somite left when the sclerotome migrates), splits to form the dermatome and the myotome. [2]
[4] [5] However, the segmentation clock model is highly evolutionarily conserved. [ 6 ] Intrinsic expression of "clock genes" must oscillate with a periodicity equal to the time necessary for one somite to form, for example 30 minutes in zebrafish, 90 minutes in chicks, and 100 minutes in snakes.
Paraxial mesoderm, also known as presomitic or somitic mesoderm, is the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. ...
A dermatome is an area of skin that is mainly supplied by afferent nerve fibres from the dorsal root of any given spinal nerve. [ 1 ] [ 2 ] There are 8 cervical nerves (C1 being an exception with no dermatome), 12 thoracic nerves , 5 lumbar nerves and 5 sacral nerves .
English: A diagram showing human dermatomes, i.e., skin regions with respect to the routing of their afferent nerves through the spinal cord. Svenska: Människans dermatom, sensoriska zonindelning. Date
The first seven somitomeres give rise to the striated muscles of the face, jaws, and throat. [2]The remaining somitomeres, likely driven by periodic expression of the hairy gene, begin expressing adhesion proteins such as N-cadherin and fibronectin, compact, and bud off forming somites.
Similarly a dermatome is an area of skin that a single nerve innervates with sensory fibers. Myotomes are separated by myosepta (singular: myoseptum ). [ 2 ] In vertebrate embryonic development , a myotome is the part of a somite that develops into muscle.
Alfred Blaschko, a private practice dermatologist from Berlin, first described and drew the patterns of the lines of Blaschko in 1901. He obtained his data by studying over 140 patients with various nevoid and acquired skin diseases and transposed the visible patterns the diseases followed onto dolls and statues, then compiled the patterns onto a composite schematic of the human body.