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Naphthoylindoles: Any compound containing a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any ...
6-MeO-THH, or 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a structural isomer of tetrahydroharmine (7-MeO-THH). 6-MeO-THH is mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved), stating that 6-MeO-THH is very similar to the other carbolines. [1]
Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine.The main feature differentiating phenyltropanes from cocaine is that they lack the ester functionality at the 3-position terminating in the benzene; and thusly the phenyl is attached direct to the tropane skeleton with no further spacer (therefore the name "phenyl"-tropane) that ...
β-Carbolines belong to the group of indole alkaloids and consist of a pyridine ring that is fused to an indole skeleton. [27] The structure of β-carboline is similar to that of tryptamine , with the ethylamine chain re-connected to the indole ring via an extra carbon atom, to produce a three-ringed structure.
Its IUPAC name is 6-methoxy-1,2,3,4-tetrahydro-β-carboline, usually abbreviated as 6-MeO-THBC, and its more common name is a combination of "pineal beta-carboline". [2] The biological activity of this molecule is of interest as a potential free radical scavenger, also known as an antioxidant , [ 3 ] and as a monoamine oxidase A inhibitor.
RCS-4 is a potent cannabinoid receptor agonist, with EC 50 values of 146 nM for human CB 1 receptors, and 46 nM for human CB 2 receptors. [2] All methoxyphenyl regioisomers, and N -butyl homologues of RCS-4 and its regioisomers also display potent agonist activities at CB 1 and CB 2 receptors.
Camptothecin (CPT) is a topoisomerase inhibitor.It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs.It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine.
c Lidocaine was found to have a value of 39.6 ± 2.4, the weakest of all tested. d Same reference gives 25.9 ± 2.4 μM for (+)-cocaine and 13.6 ± 1.3 μM for norcocaine. Comparably it gives 12.7 ± 1.5 μM for the sigmaergic affinity of (+)-amphetamine.