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Indole can also be metabolized by the liver into indoxyl sulfate, a compound that is toxic in high concentrations and associated with vascular disease and renal dysfunction. [2] AST-120 ( activated charcoal ), an intestinal sorbent that is taken by mouth , adsorbs indole, in turn decreasing the concentration of indoxyl sulfate in blood plasma.
MN-25 (UR-12) is a drug invented by Bristol-Myers Squibb, [1] that acts as a reasonably selective agonist of peripheral cannabinoid receptors. [2] It has moderate affinity for CB 2 receptors with a K i of 11 nM, but 22x lower affinity for the psychoactive CB 1 receptors with a K i of 245 nM.
Naphthoylindoles: Any compound containing a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, 1-(N-methyl-2-piperidinyl)methyl, or 2-(4-morpholinyl)ethyl group, whether or not further substituted in the indole ring to any extent and whether or not substituted in the naphthyl ring to any ...
5,7-Dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one (DMPC) is a derivative of oroxylin A. It has memory improving effects and can reduce ADHD-like behavior. It has memory improving effects and can reduce ADHD-like behavior.
6-MeO-THH, or 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a structural isomer of tetrahydroharmine (7-MeO-THH). 6-MeO-THH is mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved), stating that 6-MeO-THH is very similar to the other carbolines. [1]
Camptothecin (CPT) is a topoisomerase inhibitor.It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs.It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine.
β-Carbolines belong to the group of indole alkaloids and consist of a pyridine ring that is fused to an indole skeleton. [27] The structure of β-carboline is similar to that of tryptamine , with the ethylamine chain re-connected to the indole ring via an extra carbon atom, to produce a three-ringed structure.
Mavoglurant (developmental code name AFQ-056) is an experimental drug candidate for the treatment of fragile X syndrome and other conditions. [1] [2] It exerts its effect as an antagonist of the metabotropic glutamate receptor 5 (mGluR 5).