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Modafinil is also approved for stimulating wakefulness in people with sleep apnea and shift work sleep disorder. [3] It is taken by mouth. [3] [8] Modafinil is not approved by the US Food and Drug Administration (FDA) for use in people under 17 years old. [8] Common side effects of Modafinil include anxiety, insomnia, dizziness, and headache.
[44] [15] After onset, hypersomnia often worsens over several years, [15] but it is often stable by the time of diagnosis and appears to be a lifelong condition. [4] Spontaneous remission is only seen in 10–15% of patients. [30] [45] According to the limited epidemiological data that exists, IH "has more of a female preponderance (1.8/1)."
A Cephalon-founded study in which patients were administered modafinil, methylphenidate, and a placebo found that modafinil produces "psychoactive and euphoric effects and feelings consistent with [methylphenidate]." [12] Like modafinil, armodafinil is an inhibitor and/or inducer of certain cytochrome P450 enzymes.
Provigil was initially approved to treat excessive daytime sleepiness resulting from narcolepsy, and later approved the drug for further label indications. Cephalon allegedly promoted Provigil for a five-year period as a non-stimulant drug for the treatment of sleepiness, tiredness, decreased activity, lack of energy, and fatigue. [16]
Chemical structure of modafinil.. This page lists chemical compounds similar to modafinil, known as modafinil analogues and derivatives.These are structural analogues and derivatives of modafinil, a drug that affects dopamine levels in the brain in an unusual way (atypical dopamine reuptake inhibitor or DRI).
It is generally not recommended to take modafinil after noon; modafinil is a relatively long-acting drug with a half-life of 15 hours, and taking it during the later part of the day can make it harder to fall asleep at bedtime. [51] Vitamin B 12 was, in the 1990s, suggested as a remedy for DSPD, and is still recommended by some sources. Several ...
[1] [8] [9] [10] Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil, and adrafinil, among others. [9] They are medically indicated for the treatment of certain sleep disorders, including excessive daytime sleepiness (EDS) in narcolepsy or obstructive sleep apnea (OSA).
Modafinil, approved for narcolepsy, has been used off-label in trials with people with symptoms of PCCI. Modafinil is a wakefulness-promoting agent that can improve alertness and concentration, and studies have shown it to be effective at least among women treated for breast cancer. [32] [33] [1]
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