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Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It arises once preprocalcitonin is cleaved by endopeptidase . [ 1 ] It was first identified by Leonard J. Deftos and Bernard A. Roos in the 1970s. [ 2 ]
Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. [1] Symptoms may include fever, rash, skin peeling, and low blood pressure. [1] There may also be symptoms related to the specific underlying infection such as mastitis, osteomyelitis, necrotising fasciitis, or pneumonia. [1]
Distributive shock is different from the other three categories of shock in that it occurs even though the output of the heart is at or above a normal level. [2] The most common cause is sepsis leading to a type of distributive shock called septic shock, a condition that can be fatal. [1]
Selenium, glutamine, and eicosapentaenoic acid have shown effectiveness in improving symptoms in clinical trials. [13] [14] Other antioxidants such as vitamin E may be helpful as well. [15] Septic treatment protocol and diagnostic tools have been created due to the potentially severe outcome septic shock.
Severe sepsis is an infectious disease state associated with multiple organ dysfunction syndrome (MODS) [9] Septic shock is severe sepsis plus persistently low blood pressure, despite the administration of intravenous fluids. [9]
Vasodilatory shock, vasogenic shock, or vasoplegic shock is a medical emergency belonging to shock along with cardiogenic shock, septic shock, allergen-induced shock and hypovolemic shock. When the blood vessels suddenly relax, it results in vasodilation .
In patients with sepsis, septic shock, or multiple organ dysfunction syndrome that is due to major trauma, the rs1800625 polymorphism is a functional single nucleotide polymorphism, a part of the receptor for advanced glycation end products (RAGE) transmembrane receptor gene (of the immunoglobulin superfamily) and confers host susceptibility to ...