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Following a single dose of 500 mg, the apparent terminal elimination half-life of azithromycin is 68 hours. [8] Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination. [50] Over the course of a week, about 6% of the administered dose appears as an unchanged drug in urine. [8]
Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All aminoglycosides are ineffective when taken orally as ...
By inhibiting CYP3A4, macrolide antibitiotics, such as erythromycin and clarithromycin, but not azithromycin, can significantly increase the AUC of the drugs that depend on it for clearance, which can lead to higher risk of adverse effects or drug-drug interactions. Azithromycin stands apart from other macrolide antibiotics because it is a weak ...
Azalide. Azalides such as azithromycin are a class of macrolide antibiotics that were originally manufactured in response to the poor acid stability exhibited by original macrolides (erythromycin). [1] Following the clinical overuse of macrolides and azalides, ketolides have been developed to combat surfacing macrolide-azalide resistance among ...
Clarithromycin was developed in 1980 and approved for medical use in 1990. [ 5 ][ 6 ] It is on the World Health Organization's List of Essential Medicines. [ 7 ] Clarithromycin is available as a generic medication. [ 3 ] It is made from erythromycin and is chemically known as 6-O-methylerythromycin.
Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. [ 9 ][ 10 ] Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA ...
Clindamycin is a lincosamide antibiotic medication used for the treatment of a number of bacterial infections, including osteomyelitis (bone) or joint infections, pelvic inflammatory disease, strep throat, pneumonia, acute otitis media (middle ear infections), and endocarditis. [ 5 ]
Erythromycin was first isolated in 1952 from the bacteria Saccharopolyspora erythraea. [1][8]It is on the World Health Organization's List of Essential Medicines.[9] In 2021, it was the 259th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [10][11] Medical uses.
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