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Phoebus Aaron Theodore Levene (25 February 1869 – 6 September 1940) was a Russian-born American biochemist who studied the structure and function of nucleic acids. He characterized the different forms of nucleic acid, DNA from RNA , and found that DNA contained adenine , guanine , thymine , cytosine , deoxyribose , and a phosphate group.
The tetranucleotide hypothesis of Phoebus Levene [1] proposed that DNA was composed of repeating sequences of four nucleotides. [2] It was very influential for three decades, and was developed by Levene at least into the 1910, and the diagram at the right illustrates the view of Levene and Tipson. [3] In 1940, at the time of Levene's death ...
Hershey–Chase experiment. The Hershey–Chase experiments were a series of experiments conducted in 1952 [1] by Alfred Hershey and Martha Chase that helped to confirm that DNA is genetic material. While DNA had been known to biologists since 1869, [2] many scientists still assumed at the time that proteins carried the information for ...
t. e. " Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid " was the first article published to describe the discovery of the double helix structure of DNA, using X-ray diffraction and the mathematics of a helix transform. It was published by Francis Crick and James D. Watson in the scientific journal Nature on pages ...
According to Phoebus Levene's influential "tetranucleotide hypothesis", DNA consisted of repeating units of the four nucleotide bases and had little biological specificity. DNA was therefore thought to be the structural component of chromosomes, whereas the genes were thought likely to be made of the protein component of chromosomes.
[191] [192] [193] In 1929, Levene identified deoxyribose sugar in "thymus nucleic acid" (DNA). [194] Levene suggested that DNA consisted of a string of four nucleotide units linked together through the phosphate groups ("tetranucleotide hypothesis"). Levene thought the chain was short and the bases repeated in a fixed order.
This strongly hinted towards the base pair makeup of the DNA, although Chargaff did not explicitly state this connection himself. For this research, Chargaff is credited with disproving the tetranucleotide hypothesis [14] (Phoebus Levene's widely accepted hypothesis that DNA was composed of a large number of repeats of GACT). Most researchers ...
Nominated jointly with Ph.Levene the only time by M.T.Bogert. [217] Phoebus Levene: February 25, 1869 Žagarė, Lithuania September 6, 1940 New York City, United States 1935 Nominated jointly with G.Ol.Curme Jr. the only time by M.T.Bogert and for Nobel Prize in Physiology or Medicine too [bm] [218] [219] Colin Garfield Fink [220] December 31, 1881