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Glycerophospholipids are derived from glycerol-3-phosphate in a de novo pathway. [3] The term glycerophospholipid signifies any derivative of glycerophosphoric acid that contains at least one O-acyl, or O-alkyl, or O-alk-1'-enyl residue attached to the glycerol moiety. [4] The phosphate group forms an ester linkage to the glycerol.
It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways. Phospholipase C's role in signal transduction is its cleavage of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) into diacyl glycerol (DAG) and inositol 1,4,5 ...
The enzyme phospholipase A 2 (EC 3.1.1.4, PLA 2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule:
Their pioneering work established the structure of PI and its phosphorylated forms, shedding light on their roles as signaling molecules. Despite the complexity of inositol nomenclature and isomerism, modern research has greatly advanced the understanding of their diverse functions in cellular physiology and signaling pathways .
14829 Ensembl ENSG00000126010 ENSMUSG00000031364 UniProt P30550 P21729 RefSeq (mRNA) NM_005314 NM_008177 RefSeq (protein) NP_005305 NP_005305.1 NP_032203 Location (UCSC) Chr X: 16.12 – 16.15 Mb Chr X: 162.3 – 162.33 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The gastrin-releasing peptide receptor (GRPR), now properly known as BB 2 is a G protein-coupled receptor whose ...
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM] [7]
In enzymology, a glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15) is an enzyme that catalyzes the chemical reaction. acyl-CoA + sn-glycerol 3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate
14744 Ensembl ENSG00000140030 ENSMUSG00000021886 UniProt Q8IYL9 Q61038 RefSeq (mRNA) NM_003608 NM_008152 RefSeq (protein) NP_003599 NP_032178 Location (UCSC) Chr 14: 88.01 – 88.01 Mb Chr 12: 98.23 – 98.24 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Psychosine receptor is a G protein-coupled receptor (GPCR) protein that in humans is encoded by the GPR65 gene. GPR65 is also ...