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4-AcO-DMT is a prodrug of psilocin (4-HO-DMT). [2] As a prodrug of psilocin, 4-AcO-DMT acts as a non-selective agonist of serotonin receptors , including of the serotonin 5-HT 2A receptor . [ 1 ] The psychedelic effects of 4-AcO-DMT are mediated specifically by activation of the serotonin 5-HT 2A receptor.
Some synthetic substances like 4-AcO-DMT are thought to be prodrugs that metabolize into psychoactive substances that have been used as entheogens. While synthetic DMT and mescaline are reported to have identical entheogenic qualities as extracted or plant-based sources, the experience may wildly vary due to the lack of numerous psychoactive ...
4-HO-5-MeO-DMT (psilomethoxin) mushrooms derived from Psilocybe cubensis mycelium in substrate with added 5-MeO-DMT. [1] [2] 4-HO-DET and 4-PO-DET mushrooms derived from Psilocybe cubensis mycelium in substrate with added DET. [3] [4] 4-HO-DiPT mushrooms derived from Psilocybe cubensis mycelium in substrate with added DiPT. [2] 4-HO-DPT ...
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [1] [2] [3] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. [9]
Psilacetin (O-acetylpsilocin; 4-AcO-DMT) – non-selective serotonin receptor agonist and psychedelic hallucinogen – substance-related disorders – Psilera [180] Psilocin (PLZ-1015) – non-selective serotonin receptor agonist and psychedelic hallucinogen – pervasive child development disorders – Pilz Bioscience [ 181 ]
[12] [13] [14] [2] Both psilocybin and 4-AcO-DMT are prodrugs of the serotonergic psychedelic psilocin. [1] [15] [2] [11] Psychedelic mushroom stores operate in a legal grey area and the products sold by these stores may be either illegal controlled substances (e.g., psilocybin mushrooms, psilocybin) or legal (e.g., Amanita muscaria mushrooms ...
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In rodents, 4-HO-TMT showed no head-twitch response (a behavioral proxy of psychedelic effects), hypolocomotion, or hypothermia, in contrast to psilocin and norpsilocin, but similarly to aeruginascin. [3] A synthetic prodrug of 4-HO-TMT, 4-AcO-TMT, has been developed. [1] [5] It is analogous to psilacetin (4-AcO-DMT), a prodrug of psilocin. [1] [5]