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The insufflation of cocaine crystals may also cause physical trauma to epithelial cells, leading to inflammatory lesions, which may also worsen due to the tendency for patients to physically remove the scabs produced in the damaged tissue, which induces further mechanical damage. [6] Cocaine is capable of inducing apoptosis of epithelial cells ...
A medical professional applies nose drops. Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose.It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects.
Any damage to the inside of the nose is due to cocaine constricting blood vessels — and therefore restricting blood and oxygen/nutrient flow — to that area. Rolled up banknotes, hollowed-out pens, cut straws, pointed ends of keys, specialized spoons, [57] long fingernails, and (clean) tampon applicators are often used to insufflate cocaine.
Troubled comedian Artie Lange, 51, revealed he would be attending rehab after testing positive for multiple drugs, including cocaine, while serving his four-year probation for heroin possession.
Cocaine and methamphetamine, for example, both increase levels of dopamine in the brain, albeit through different processes. As a result, people using cocaine may respond and behave very ...
A snuff spoon is a tiny spoon used for nasal insufflation of powdered substances. Historically, such spoons were used to ingest psychotropic substances in pre-Columbian America , [ 1 ] then tobacco in the 18th century, [ 2 ] and cocaine in the 20th century, hence the names cocaine spoon and coke spoon .
The fight against cocaine intensified between 2000 and 2015 with "Plan Colombia", a billion dollar campaign by the U.S. to help Colombia battle drugs. "Despite our best efforts, illegal cocaine is ...
Nasal insufflation is the most common method of nasal administration. Other methods are nasal inhalation and nasal instillation. Drugs administered in this way can have a local effect or a systemic effect. The time of onset for systemic drugs delivered via nasal administration is generally only marginally slower than if given intravenously.