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Fructosamines are compounds that result from glycation reactions between glucose and a primary amine, followed by isomerization via the Amadori rearrangement.Biologically, fructosamines are recognized by fructosamine-3-kinase, which may trigger the degradation of advanced glycation end-products (though the true clinical significance of this pathway is unclear).
64122 63828 Ensembl ENSG00000167363 ENSMUSG00000025175 UniProt Q9H479 Q9ER35 RefSeq (mRNA) NM_022158 NM_001038699 NM_022014 RefSeq (protein) NP_071441 NP_001033788 NP_071297 Location (UCSC) Chr 17: 82.74 – 82.75 Mb Chr 11: 121.33 – 121.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fructosamine-3-kinase is an enzyme that in humans is encoded by the FN3K gene. Function FN3K ...
As the formation of glucosamine-6-phosphate is the first step for the synthesis of these products, glucosamine may be important in regulating their production; however, the way that the hexosamine biosynthesis pathway is actually regulated, and whether this could be involved in contributing to human disease remains unclear. [17]
Protein-fructosamine 3-kinase (EC 2.7.1.171, FN3K, fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N 6-D-fructosyl-L-lysine 3-phosphotransferase. [ 1 ] [ 2 ] This enzyme catalyses the following chemical reaction
Chemical structure of α-D-glucosamine.Note amine group (NH 2). Glucose.Note hydroxy group (OH) in place of the amine.. Hexosamines are amino sugars created by adding an amine group to a hexose.
Fructose malabsorption, formerly named dietary fructose intolerance (DFI), is a digestive disorder [1] in which absorption of fructose is impaired by deficient fructose carriers in the small intestine's enterocytes.
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August 2, 1985: Delta Air Lines Flight 191, a Lockheed L-1011 on a Fort Lauderdale–Dallas/Fort Worth–Los Angeles route, crashed near the north end of runway 17L (now 17C) after encountering a severe microburst on final approach; the crash killed 8 of 11 crew members, 128 of 152 passengers on board and one person on the ground. This was the ...