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A 10-mg oral capsule of dicyclomine hydrochloride. Dicycloverine was first synthesized chemically in the United States circa 1945 by scientists at William S. Merrell Company. [12] It was first marketed in 1952 for gastrointestinal disorders, including colic in infants. [9] The INN name "dicycloverine" was recommended in 1959. [13]
Metopimazine is an approved prescription drug in France under the brand name Vogalene® [8] that has been used for the treatment of nausea and vomiting. [9] Vogalene® is available under different forms, including 15 mg capsules, 7.5 mg orally disintegrating tablets, 5 mg suppository, 0.1% oral liquid, and a 10 mg/mL intravenous (IV) solution approved for the prevention of chemotherapy-induced ...
Prucalopride, sold under brand names Resolor and Motegrity among others, is a medication acting as a selective, high affinity 5-HT 4 receptor agonist [4] which targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.
Heather Finley, a registered dietitian, adds, "This this technique might help relieve constipation because it could be stimulating acupressure points that stimulate the colon, but there is no ...
A 2018 pooled analysis from three phase III, randomized, double-blind, placebo-controlled studies on usage for Opioid-Induced Constipation, found that the numbers of patients reporting adverse effects were similar in both the lubiprostone and placebo treatment groups for all opioid classes (P ≥ 0.125); however, gastrointestinal adverse ...
Bisacodyl is an organic compound that is used as a stimulant laxative drug. It works directly on the colon to produce a bowel movement. It is typically prescribed for relief of episodic and chronic constipation and for the management of neurogenic bowel dysfunction, as well as part of bowel preparation before medical examinations, such as for a colonoscopy.
Sucralfate is used for the treatment of active duodenal ulcers not related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs), as the mechanism behind these ulcers is due to acid oversecretion. [1] It is not FDA approved for gastric ulcers, but is widely used because of evidence of efficacy. [10]
Mebeverine is an anticholinergic but its mechanism of action is not known; it appears to work directly on smooth muscle within the gastrointestinal tract and may have an anaesthetic effect, may affect calcium channels, and may affect muscarinic receptors.
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