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A mechanistic studying of clofazimine in human T cells revealed that this drug is a Kv1.3 channel blocker. [22] This indicates that clofazimine will be potentially used for treatment of multiple sclerosis , rheumatoid arthritis and type 1 diabetes .
Pages in category "4-Chlorophenyl compounds" The following 200 pages are in this category, out of approximately 257 total. This list may not reflect recent changes .
Maleimide-mediated methodologies are among the most used in bioconjugation. [5] [6] Due to fast reactions and high selectivity towards cysteine residues in proteins, a large variety of maleimide heterobifunctional reagents are used for the preparation of targeted therapeutics, assemblies for studying proteins in their biological context, protein-based microarrays, or proteins immobilisation. [7]
In one example, 4-chlorophenylacetonitrile is reacted with 2-chloropyridine in the presence of sodium amide to form 4-chlorophenyl(2-pyridyl)acetonitrile. Alkylating this with 2-dimethylaminoethylchloride in the presence of sodium amide gives γ-(4-chlorphenyl)-γ-cyano- N , N -dimethyl-2-pyridinepropanamine, the hydrolysis and decarboxylation ...
Rilmazafone [1] (リスミー, Rhythmy, previously known as 450191-S) is a water-soluble prodrug developed in Japan. [2] Inside the human body, rilmazafone is converted into several benzodiazepine metabolites that have sedative and hypnotic effects. [3] [4] [5]
4-Chlorophenylisobutylamine (4-CAB, AEPCA), also known as 4-chloro-α-ethylphenethylamine, is an entactogen and stimulant drug of the phenethylamine, amphetamine, and phenylisobutylamine families. [1] It is an analogue of para-chloroamphetamine (PCA) where the alpha position methyl has been replaced with an ethyl group. [1]
4-Chlorophenol is an organic compound with the formula C 6 H 4 ClOH. It is one of three monochlorophenol isomers. It is a colorless or white solid that melts easily and exhibits significant solubility in water.
4-Phenylthiosemicarbazide (4-PTSC) is a thiosemicarbazide used as an agricultural chemical and pesticide. It also possesses antibacterial properties attributed to electron delocalization in the thiosemicarbazide moiety .