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Salicylate toxicity also causes an uncoupling of oxidative phosphorylation and a decrease in citric acid cycle activity in the mitochondria. [9] This decrease in aerobic production of adenosine triphosphate (ATP) is accompanied by an increase in anaerobic production of ATP through glycolysis which leads to glycogen depletion and hypoglycemia. [9]
Signs and symptoms of ototoxicity include tinnitus, hearing loss, dizziness and nausea and/or vomiting. [3] The diagnosis of medicine-induced ototoxicity is challenging as it usually shows only mild symptoms in early stages. Thus, prospective ototoxicity monitoring would be required when patients are using ototoxic medications. [1]
Ototoxicity of gentamicin can be exploited to treat some individuals with Ménière's disease by destroying the inner ear, which stops the vertigo attacks but causes permanent deafness. [19] Due to the effects on mitochondria, certain inherited mitochondrial disorders result in increased sensitivity to the toxic effects of aminoglycosides.
First-line treatment options are generally aimed at treating the underlying cause and include attempting to "pop" the ears, usually via the Valsalva maneuver, the use of oral or topical decongestants, oral steroids, oral antihistamines, and topical nasal steroid sprays, such as Flonase.
The best-supported treatment for tinnitus is cognitive behavioral therapy (CBT). [5] [84] [102] It decreases the stress those with tinnitus feel. [103] This appears to be independent of any effect on depression or anxiety. [102] Acceptance and commitment therapy (ACT) also shows promise in the treatment of tinnitus. [104] Relaxation techniques ...
Tinnitus Today [8] is a magazine focused on the tinnitus patient community, tinnitus research, and the healthcare providers who see tinnitus patients. The publication provides inspiring tinnitus patient stories, tinnitus management strategies, tinnitus treatment information, tinnitus help tools, and news and updates on innovative tinnitus research.
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The symptoms of cochlear hydrops fluctuate, and the condition may stabilize or go away on its own after several years. However, because the organ of Corti undergoes stress during the hydrops episodes, long-term hearing loss, tinnitus, or hyperacusis is possible. It is considered by some that cochlear hydrops is an early form of Meniere's disease.
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