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Signs and symptoms of ototoxicity include tinnitus, hearing loss, dizziness and nausea and/or vomiting. [3] The diagnosis of medicine-induced ototoxicity is challenging as it usually shows only mild symptoms in early stages. Thus, prospective ototoxicity monitoring would be required when patients are using ototoxic medications. [1]
Salicylate toxicity also causes an uncoupling of oxidative phosphorylation and a decrease in citric acid cycle activity in the mitochondria. [9] This decrease in aerobic production of adenosine triphosphate (ATP) is accompanied by an increase in anaerobic production of ATP through glycolysis which leads to glycogen depletion and hypoglycemia. [9]
Ototoxicity of gentamicin can be exploited to treat some individuals with Ménière's disease by destroying the inner ear, which stops the vertigo attacks but causes permanent deafness. [19] Due to the effects on mitochondria, certain inherited mitochondrial disorders result in increased sensitivity to the toxic effects of aminoglycosides.
The best-supported treatment for tinnitus is cognitive behavioral therapy (CBT). [5] [84] [102] It decreases the stress those with tinnitus feel. [103] This appears to be independent of any effect on depression or anxiety. [102] Acceptance and commitment therapy (ACT) also shows promise in the treatment of tinnitus. [104] Relaxation techniques ...
Early symptoms include headache, dizziness, fast heart rate, shortness of breath, and vomiting. [2] This phase may then be followed by seizures, slow heart rate, low blood pressure, loss of consciousness, and cardiac arrest. [2] Onset of symptoms usually occurs within a few minutes. [2] [3] Some survivors have long-term neurological problems. [2]
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Tinnitus Today [8] is a magazine focused on the tinnitus patient community, tinnitus research, and the healthcare providers who see tinnitus patients. The publication provides inspiring tinnitus patient stories, tinnitus management strategies, tinnitus treatment information, tinnitus help tools, and news and updates on innovative tinnitus research.
The Mayo Clinic diet, a program that adheres to this notion, was developed by medical professionals based on scientific research, so you can trust that this program is based on science, and not ...
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