Search results
Results from the WOW.Com Content Network
Pyrrolizidine alkaloids (PAs), sometimes referred to as necine bases, are a group of naturally occurring alkaloids based on the structure of pyrrolizidine. Their use dates back centuries and is intertwined with the discovery, understanding, and eventual recognition of their toxicity on humans and animals.
Like other pyrrolizidine alkaloids, senecionine is toxic when ingested. The ingested molecule is a protoxin that is metabolized to its active form. [3] In large quantities, ingestion can lead to critical illness, including convulsions and death. Studies in rodents have shown an LD 50 of 65 mg/kg. [4]
Pyrrolizidine is a heterocyclic organic compound. Formally, it is a saturated derivative of pyrrolizine. Pyrrolizidine forms the central chemical structure of a variety of alkaloids known collectively as pyrrolizidine alkaloids. [1] It is one of five classes of iminosugars. These are often synthesized from a carbohydrate. [2]
Riddelliine is a naturally occurring pyrrolizidine alkaloid, a class of compounds occurring in rangeland plants of the genera Crotalaria, Amsinckia, and Senecio. [5] It consists of a macrocyclic diester of retronecine (an unsaturated alcohol) and riddelliic acid (an oxygenated, branched, dicarboxylic acid). [5]
Pages in category "Pyrrolizidine alkaloids" The following 12 pages are in this category, out of 12 total. This list may not reflect recent changes. ...
[4] [5] It has had uses in traditional medicine, but the discovery of toxic pyrrolizidine alkaloids in the plant has resulted in liver health concerns. Tussilago farfara is the only accepted species in the genus Tussilago, although more than two dozen other species have at one time or another been considered part of this group.
From its endless beauty tricks and home hacks, vinegar is one of the most beneficial products out there. Trust us. Related: Scroll through for more life-changing household hacks
Pyrrolizidine alkaloids (contained in comfrey, borage, senecio, coltsfoot, and others) Liver damage [5] Reserpine: Rauvolfia serpentina "Sedation, inability to complete tasks, mental depression, nasal congestion, increased gastric secretion and mild diarrhea" [3] Safrole: Sassafras albidum: Liver damage [3] Saw palmetto: Serenoa repens