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The minimum inhibitory concentration, which is the lowest concentration of the antibiotic that stops the growth of bacteria, can be estimated from the size of the zone of inhibition. Antibiotic susceptibility testing has been needed since the discovery of the beta-lactam antibiotic penicillin. Initial methods were phenotypic, and involved ...
Nowadays, the MIC is used in antimicrobial susceptibility testing. The MIC is reported by providing the susceptibility interpretation next to each antibiotic. The different susceptibility interpretations are: "S" (susceptible or responding to a standard dosing regimen), "I" (intermediate or requiring increased exposure), and "R" (resistant).
The maximal information coefficient uses binning as a means to apply mutual information on continuous random variables. Binning has been used for some time as a way of applying mutual information to continuous distributions; what MIC contributes in addition is a methodology for selecting the number of bins and picking a maximum over many possible grids.
European Committee on Antimicrobial Susceptibility Testing (EUCAST) is a scientific committee for defining guidelines to interpret antimicrobial resistance. [1] It was formed in 1997 and is jointly organized by ESCMID , ECDC and other European laboratories.
Online IC50 calculator (www.ic50.tk) based on the C programming language and gnuplot; Alternative online IC50 calculator (www.ic50.org) based on Python, NumPy, SciPy and Matplotlib; ELISA IC50/EC50 Online Tool (link seems broken) IC50 to pIC50 calculator; Online tool for analysis of in vitro resistance to antimalarial drugs
Segmented linear regression with two segments separated by a breakpoint can be useful to quantify an abrupt change of the response function (Yr) of a varying influential factor (x). The breakpoint can be interpreted as a critical , safe , or threshold value beyond or below which (un)desired effects occur.
Some programming language implementations expose their debugging functions for use by other programs. For example, some FORTRAN dialects have an AT statement, which was originally intended to act as an instruction breakpoint. Python implements a debugger accessible from a Python program. [6]
The broth microdilution method can be used to test the susceptibility of microorganisms to multiple antibiotics at once. [4] Broth microdilution is also highly accurate. The accuracy of its results are comparable to agar dilution, the gold standard of susceptibility testing. Other advantages include the commercial availability of plates, the ...