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Primary bile acid diarrhea (Type 2 bile acid "malabsorption") may be caused by an overproduction of bile acids. [5] [9] Several groups of workers have failed to show any defect in ileal bile acid absorption in these patients, and they have an enlarged bile acid pool, rather than the reduced pool expected with malabsorption. [10]
Dietary modification is important in some conditions: Gluten-free diet in coeliac disease. Lactose avoidance in lactose intolerance. Antibiotic therapy to treat Small Bowel Bacterial overgrowth. Cholestyramine or other bile acid sequestrants will help with reducing diarrhoea in bile acid malabsorption.
In addition to this, bile also plays a role in fat absorption, where dietary lipids are combined so that pancreatic lipases can hydrolyze them before going towards the small intestine. Without bile acids, this pathway would have a hard time occurring, which would lead to fat malabsorption and make steatorrhea more probable to occur. [2]
Primary bile acid malabsorption, a gut defect in the reabsorption of bile acids in the small intestine which results in increased levels of bile acids in the colon leading to watery diarrhea and bloating. [31] Chronic infection of C. difficile, G. lamblia. C. difficile — bacteria that can be the source of diarrhea. [32]
Typically, the patient is recommended a dietary restriction table with fatty foods, enzyme preparations, antispasmodics, and sometimes cholagogue. [citation needed] If the pain is caused by biliary microlithiasis, oral ursodeoxycholic acid can alleviate the condition. [5] A trial of bile acid sequestrant therapy is recommended for bile acid ...
The liver then produces more bile acids to replace those that have been lost. Because the body uses cholesterol to make bile acids, this reduces the level of LDL cholesterol circulating in the blood. [2] Bile acid sequestrants are large polymeric structures, and they are not significantly absorbed from the gut into the bloodstream.
2 Abstract Although recent legislation has been enacted to require fast-food restaurants to display calorie information on menus, the consequences of posting such information remain unclear.
Bypassing the major site of bile acid reabsorption in the small intestine therefore further reduces fat and fat-soluble vitamin absorption. As a result, huge amounts of fatty acids , which are normally absorbed in the small intestine, enter the colon, where they cause irritation of the colon wall and the secretion of excessive volumes of water ...