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Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene. [5] [6]The TNNI2 gene is located at 11p15.5 in the human chromosomal genome, encoding the fast twitch skeletal muscle troponin I (fsTnI). fsTnI is a 21.3 kDa protein consisting of 182 amino acids including the first methionine with an isoelectric point (pI) of 8.74.
Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene. [5] [6] Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.
Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that are integral to muscle contraction [2] in skeletal muscle and cardiac muscle, but not smooth muscle.
Fast skeletal muscle troponin T (fTnT) is a protein that in humans is encoded by the TNNT3 gene. [5] [6]The TNNT3 gene is located at 11p15.5 in the human genome, encoding the fast skeletal muscle isoform of troponin T (fsTnT). fsTnT is an ~31-kDa protein consisting of 268 amino acids including the first methionine with an isoelectric point (pI) of 6.21 (embryonic form). fsTnT is the ...
Test Sensitivity and specificity Approximate peak Description Troponin test: The most sensitive and specific test for myocardial damage. Because it has increased specificity compared with CK-MB, troponin is composed of 3 proteins- Troponin C, Cardic troponin I, and Cardiac troponin T. Troponin I especially has a high affinity for myocardial injury.
It occurs in different plasma concentration but the same circumstances as troponin T - either test can be performed for confirmation of cardiac muscle damage and laboratories usually offer one test or the other. [3] Three paralogs with unique tissue-specific expression patterns are expressed in humans, listed below with their locations and OMIM ...
Before and after photos of the deadly wildfires in the Los Angeles area have sent tens of thousands scrambling for safety and decimated neighborhoods.
21954 Ensembl ENSG00000129991 ENSMUSG00000035458 UniProt P19429 Q6FGX2 P48787 RefSeq (mRNA) NM_000363 NM_009406 RefSeq (protein) NP_000354 NP_000354.4 NP_033432 Location (UCSC) Chr 19: 55.15 – 55.16 Mb Chr 7: 4.52 – 4.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene. It is a tissue-specific ...
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