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The antidotes for ethylene glycol poisoning are ethanol and fomepizole. This antidotal treatment forms the mainstay of management of ethylene glycol poisoning. The toxicity of ethylene glycol comes from its metabolism to glycolic acid and oxalic acid. The goal of pharmacotherapy is to prevent the formation of these metabolites.
Ethylene glycol, antifreeze, is extremely toxic to dogs. It has a sweet taste and thus dogs will drink it. As little as 2 1/2 tablespoons can kill a medium-sized dog in 2–3 days. This type of poisoning is often fatal as dog owners do not know their pet has ingested the antifreeze. De-icing fluids can also contain ethylene glycol.
The effect of ethanol on dogs and cats is similar to its effect on humans, also causing intoxication. Death is unlikely given supportive care (only one death is known). Ethanol is also an antidote for ethylene glycol poisoning. [47] Mouse and rat poison, anticoagulant type Rodenticide is commonly found in the house or garage.
2022 – At least 40 dogs died in Brazil after consuming Bassar produced snacks for dental care [113] that were also sold under the Petz [114] brand. The snacks were contaminated with ethylene glycol, probably originating from contamined propylene glycol. All products made by Bassar were recalled on the 7th of September. [113]
Cats can succumb quickly from ethylene glycol poisoning, after ingesting as little as one teaspoon. [35] The primary source of ethylene glycol is automotive antifreeze or radiator coolant, where concentrations are high. [35]
Image credits: nani.mtz For many owners, having a pet is somewhat like having a child. You love your furry little friend unconditionally, and you are responsible for their wellbeing.
Ethylene glycol has relatively high mammalian toxicity when ingested, roughly on par with methanol, with an oral LD Lo = 786 mg/kg for humans. [30] The major danger is due to its sweet taste, which can attract children and animals. Upon ingestion, ethylene glycol is oxidized to glycolic acid, which is, in turn, oxidized to oxalic acid, which is ...
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