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4-AcO-DMT is a prodrug of psilocin (4-HO-DMT). [2] As a prodrug of psilocin, 4-AcO-DMT acts as a non-selective agonist of serotonin receptors , including of the serotonin 5-HT 2A receptor . [ 1 ] The psychedelic effects of 4-AcO-DMT are mediated specifically by activation of the serotonin 5-HT 2A receptor.
[12] [13] [14] [2] Both psilocybin and 4-AcO-DMT are prodrugs of the serotonergic psychedelic psilocin. [1] [15] [2] [11] Psychedelic mushroom stores operate in a legal grey area and the products sold by these stores may be either illegal controlled substances (e.g., psilocybin mushrooms, psilocybin) or legal (e.g., Amanita muscaria mushrooms ...
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [1] [2] [3] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. [9]
[16] [6] 4-AcO-DMT, a synthetic analogue of psilocybin (4-PO-DMT), is a prodrug of psilocin similarly to psilocybin itself. [3] [17] [14] Mushroom edibles may also contain completely unrelated substances and drugs, with identified compounds having included bath salts, 4-AcO-DET, the scheduled prescription drug pregabalin, and kava constituents ...
Beans: 5-MeO-DMT. Up to 12.4% bufotenin. [33] DMT Psychedelic: There have been reports of active use of vilca by Wichi shamans, under the name hatáj. [34] Yopo: Anadenanthera peregrina: Beans: 5-MeO-DMT. Up to 7.4% bufotenin. [33] DMT Psychedelic: Archaeological evidence of insufflation use within the period 500-1000 AD, in northern Chile, has ...
Psilacetin (O-acetylpsilocin; 4-AcO-DMT) – non-selective serotonin receptor agonist and psychedelic hallucinogen – substance-related disorders – Psilera [180] Psilocin (PLZ-1015) – non-selective serotonin receptor agonist and psychedelic hallucinogen – pervasive child development disorders – Pilz Bioscience [ 181 ]
4-acetoxy-MET (4-acetoxy-N-methyl-N-ethyl tryptamine), also known as 4-AcO-MET or metacetin, is a hallucinogenic tryptamine. It is the acetate ester of 4-HO-MET, and a homologue of 4-AcO-DMT. It is a novel compound with very little history of human use. [2] It is sometimes sold as a research chemical by online retailers.
In rodents, 4-HO-TMT showed no head-twitch response (a behavioral proxy of psychedelic effects), hypolocomotion, or hypothermia, in contrast to psilocin and norpsilocin, but similarly to aeruginascin. [3] A synthetic prodrug of 4-HO-TMT, 4-AcO-TMT, has been developed. [1] [5] It is analogous to psilacetin (4-AcO-DMT), a prodrug of psilocin. [1] [5]