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Drug-induced angioedema is a known complication of the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists (ARBs), and Angiotensin-Neprilysin Inhibitor LCZ969. [ 1 ] : 120 The angioedema appears to be dose dependent as it may resolve with decreased dose.
The incidence of these adverse effects is not totally known as the scarcity of well-designed clinical trials involving doxepin prohibits it. Side effects that are common (based on its pharmacology or the frequency of these side effects with related agents) appear with a * superscript whereas the serious side effects are in bold .
Doxepin is a medication belonging to the tricyclic antidepressant (TCA) [10] class of drugs used to treat major depressive disorder, anxiety disorders, chronic hives, and insomnia. [ 10 ] [ 11 ] For hives it is a less preferred alternative to antihistamines . [ 10 ]
Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes. [1] [3] The swelling may occur in the face, tongue, larynx, abdomen, or arms and legs. [1] Often it is associated with hives, which are swelling within the upper skin. [1] [3] Onset is typically over minutes to hours. [1]
Typical areas of swelling include the face, arms, and legs, while internally some individuals have swelling of the tongue and upper airways. [3] In contrast to hereditary angioedema, there tend to be fewer symptoms of the abdomen or gastrointestinal tract, but symptoms of nausea, vomiting, and diarrhea have been seen in acquired angioedema. [3]
Doxepin has been used to treat angiodema and severe allergic reactions due to its strong antihistamine properties. [8] Diphenhydramine, known in the US as Benadryl, is approved for treatment of allergies, but is also used off label for nausea, anxiety, and more. [9] [10]
The antidepressant doxepin (Silenor) Certain other medications may also sometimes be used off-label for insomnia. This means a drug is being prescribed for a condition it isn’t FDA-approved to ...
Cidoxepin (former developmental code name P-4599), also known as cis-doxepin or (Z)-doxepin, is a tricyclic antidepressant which was developed in the 1960s but was never marketed. [ 1 ] [ 2 ] It is the cis or ( Z ) stereoisomer of doxepin , a mixture of ( E ) and ( Z ) isomers that is used commercially in a ratio of approximately 85:15 with ...