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Chlorophacinone is a first-generation anticoagulant rodenticide. The mechanism of action results in internal bleeding due to non-functional clotting factors. It was used as a toxin to control rodent populations.
Anticoagulants are defined as chronic (death occurs one to two weeks after ingestion of the lethal dose, rarely sooner), single-dose (second generation) or multiple-dose (first generation) rodenticides, acting by effective blocking of the vitamin-K cycle, resulting in inability to produce essential blood-clotting factors—mainly coagulation factors II (prothrombin) and VII (proconvertin).
A poisoned animal suffers progressively worsening internal bleeding, leading to shock, loss of consciousness, and eventually death. [citation needed] Brodifacoum is highly lethal to mammals and birds, and extremely lethal to fish. It is a highly cumulative poison, due to its high lipophilicity and extremely slow elimination. [citation needed]
When it comes to protecting our canine companions from the persistent threat of fleas and ticks, choosing the right medicine is of paramount importance. These pesky parasites not only cause ...
Rodenticide is commonly found in the house or garage. This anticoagulant class of poison works by depleting stores of Vitamin K in the body; without these stores, blood cannot clot properly. Clinical signs of poisoning include depression, weakness, difficulty breathing, bruising, and bleeding from any part of the body.
Vitamin K deficiency causes internal bleeding and hemorrhaging, resulting in a slow, painful death. Other vitamin K deficient states include: biliary obstruction, intrahepatic cholestasis, intestinal malabsorption and chronic oral antibiotic administration.
Flea infestation in the home is treated in various ways. Insecticides.A spot-on insecticide kills the fleas on the pet. A fogger or spray insecticide containing an insect growth regulator, such as pyriproxyfen or methoprene can kill eggs and pupae, which are quite resistant to insecticides.
Bromadiolone is a potent anticoagulant rodenticide. It is a second-generation 4-hydroxycoumarin derivative and vitamin K antagonist, often called a "super-warfarin" for its added potency and tendency to accumulate in the liver of the poisoned organism. When first introduced to the UK market in 1980, it was effective against rodent populations ...
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