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A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component. [1] [2] [3] It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or ...
5-Ethynyl-2′-deoxyuridine (EdU) is a thymidine analogue which is incorporated into the DNA of dividing cells. EdU is used to assay DNA synthesis in cell culture and detect cells in embryonic, neonatal and adult animals which have undergone DNA synthesis. [ 1 ]
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.. In the past, derivative also meant a compound that can be imagined to arise from another compound, if one atom or group of atoms is replaced with another atom or group of atoms, [1] but modern chemical language now uses the term structural analog for this meaning, thus eliminating ambiguity.
Functional analogs are not necessarily structural analogs with a similar chemical structure. [1] An example of pharmacological functional analogs are morphine , heroin and fentanyl , which have the same mechanism of action, but fentanyl is structurally quite different from the other two with significant variance in dosage.
An overview of the different components included in the field of chemical biology. Chemical biology is a scientific discipline between the fields of chemistry and biology.The discipline involves the application of chemical techniques, analysis, and often small molecules produced through synthetic chemistry, to the study and manipulation of biological systems. [1]
Studies shown that a boronic acid moiety adopts a tetrahedral configuration and serves as an inhibitor. In addition, the sulfonamide functional group can also mimic the transition state structure. [12] Evidence of boronic acid mimics as transition state analogue inhibitors of human arginase I was elucidated by x-ray crystal structures. [13]
Also, in the same family of cytosine analogues, a FRET-acceptor base analogue, tC nitro, has been developed. [24] Together with tC O as a FRET-donor this constitutes the first nucleic acid base analogue FRET-pair ever developed. The tC-family has, for example, been used in studies related to polymerase DNA-binding and DNA-polymerization mechanisms.
The effect of the substrate analog can be nullified by increasing the concentration of the originally intended substrate. [6] There are also substrate analogs that bind to the binding site of an enzyme irreversibly. If this is the case, the substrate analog is called an inhibitory substrate analog, a suicide substrate, or a Trojan horse ...