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At steady state, the systemic exposure for armodafinil is 1.8 times the exposure observed after a single dose. The concentration-time profiles of the ( R )-(−)-enantiomer following a single dose of 50 mg Nuvigil or 100 mg Provigil (modafinil being a 1:1 mixture of ( R )-(−)- and ( S )-(−)- enantiomers) are nearly superimposable.
Modafinil is a drug that helps keep people awake and alert (wakefulness-promoting agent or "eugeroic"). [ 1 ] [ 2 ] Most of the listed modafinil analogues are drugs that specifically target dopamine reuptake (reabsorption of a neurotransmitter by a neurotransmitter transporter ) with stronger effects ( selective DRIs with improved potency ...
clomipramine – primarily used in dogs to treat behavioral problems; D ... This page was last edited on 8 August 2024, at 12:20 (UTC).
[2] [8] Unlike modafinil, flmodafinil does not induce cytochrome P450 enzymes. [2] Chemically, flmodafinil is an enantiopure derivative of modafinil and is also known as bisfluoromodafinil (it is the (R)-bis(4-fluoro) phenyl ring-substituted derivative of modafinil). [2] [8] Flmodafinil was developed by NLS Pharma. [3]
The last vaccination needs to be given after about 20 weeks (5 months), so the most common recommendation is to finish at about 16 weeks and then give a booster at one year of age.
A dog's glans consists of two sections: Behind the lower, long part (pars longa glandis) lies the "knot" (Bulbus glandis) [1] which expands only after penetrating the vagina and causes the male dog to remain inside the bitch ("Tie") for some time after ejaculation (typically between 15 and 30 min).
Guy Pearce is not ashamed of his soap-opera past.. In fact, after the 57-year-old actor got his start on the Australian soap Neighbours in the 1980s, he later reprised his character Mike Young on ...
In 1976, two years after the discovery of adrafinil, its active metabolite modafinil was discovered. [18] Modafinil appeared to be more potent than adrafinil in animal studies, and was selected for further clinical development, with both adrafinil and modafinil eventually reaching the market. [ 18 ]
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