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  2. Metoprolol - Wikipedia

    en.wikipedia.org/wiki/Metoprolol

    The specific agent in on-market formulations of metoprolol is either metoprolol tartrate or metoprolol succinate, where tartrate is an immediate-release formulation and the succinate is an extended-release formulation (with 100 mg metoprolol tartrate corresponding to 95 mg metoprolol succinate). [41]

  3. Modified-release dosage - Wikipedia

    en.wikipedia.org/wiki/Modified-release_dosage

    Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]

  4. Beta blocker - Wikipedia

    en.wikipedia.org/wiki/Beta_blocker

    [14] [15] [16] Bisoprolol, carvedilol, and sustained-release metoprolol are specifically indicated as adjuncts to standard ACE inhibitor and diuretic therapy in congestive heart failure, although at doses typically much lower than those indicated for other conditions. Beta blockers are only indicated in cases of compensated, stable congestive ...

  5. Elimination rate constant - Wikipedia

    en.wikipedia.org/wiki/Elimination_rate_constant

    And since is fraction of the drug that is removed per unit time measured at any particular instant, then if we divide the rate of elimination by the amount of drug in the body at time t, we get; K = d E t d t ÷ A t = ln ⁡ 2 t 1 / 2 ≈ 0.693 t 1 / 2 {\displaystyle K={dE_{t} \over dt}\div A_{t}={\frac {\ln 2}{t_{1/2}}}\approx {\frac {0.693}{t ...

  6. Is There a "Best Time" to Take Metformin? - AOL

    www.aol.com/best-time-metformin-115700262.html

    Well, there’s no magic time, but you should take metformin at the same time each day and with food to avoid gastrointestinal side effects. If you’re taking extended-release metformin tablets ...

  7. Ophthalmic drug administration - Wikipedia

    en.wikipedia.org/wiki/Ophthalmic_drug_administration

    The rate of release of a drug is also important because too slow of a release could have no beneficial outcome for the patient and a release that is too quick could result in negative side effects. [ 10 ] [ 14 ] [ 16 ] [ 17 ] Thus, it is important to balance the factors that govern the release of drugs from contact lenses as potential drug ...

  8. First-dose phenomenon - Wikipedia

    en.wikipedia.org/wiki/First-dose_phenomenon

    The first-dose phenomenon is a sudden and severe fall in blood pressure that can occur when changing from a lying to a standing position the first time that an alpha blocker drug is used [1] or when resuming the drug after many months off. [2]

  9. Extended-release morphine - Wikipedia

    en.wikipedia.org/wiki/Extended-release_morphine

    Extended-release (or slow-release) formulations of morphine are those whose effect last substantially longer than bare morphine, availing for, e.g., one administration per day. Conversion between extended-release and immediate-release (or "regular") morphine is easier than conversion to or from an equianalgesic dose of another opioid with ...

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