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2. Melatonin as a medication and supplement - Wikipedia

   en.wikipedia.org/wiki/Melatonin_as_a_medication...

   [43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.

3. Melatonin - Wikipedia

   en.wikipedia.org/wiki/Melatonin

   Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.

4. Modified-release dosage - Wikipedia

   en.wikipedia.org/wiki/Modified-release_dosage

   Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]

5. Is melatonin or ashwagandha better for sleep? Experts weigh in

   www.aol.com/finance/melatonin-ashwagandha-better...

   For those who wake up in the middle of the night, he recommends a sustained release of a higher dose of melatonin. To reap the sleep benefits of ashwagandha, he says the supplement must be at ...

6. Ramelteon - Wikipedia

   en.wikipedia.org/wiki/Ramelteon

   Ramelteon is an analogue of melatonin and is a selective agonist of the melatonin MT 1 and MT 2 receptors. [3] The half-life and duration of ramelteon are much longer than those of melatonin. [7] Ramelteon is not a benzodiazepine or Z-drug and does not interact with GABA receptors, instead having a distinct mechanism of action. [3] [8]

7. Sleepmaxxing, A Trend Expected To Revolutionize Our Sleep, Is ...

   www.aol.com/lifestyle/viral-sleepmaxxing-trend...

   There are beliefs that melatonin might help with sleep issues temporarily, especially those caused by jet lag, but its side effects include short-term feelings of depression, mild anxiety ...