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The neural crest is a ridge-like structure that is formed transiently between the epidermal ectoderm and neural plate during vertebrate development. Neural crest cells originate from this structure through the epithelial-mesenchymal transition, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, dentin, peripheral and enteric ...
Parietal epithelial cell (PEC) Podocyte; Angioblast → Endothelial cell; Mesangial cell. Intraglomerular; Extraglomerular; Juxtaglomerular cell; Macula densa cell; Stromal cell → Interstitial cell → Telocytes; Kidney proximal tubule brush border cell; Kidney distal tubule cell; Connecting tubule cells; α-intercalated cell; β-intercalated ...
The Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells) and sub-types in the human body". [13] By 2018, the Human Cell Atlas description based the project on the assumption that "our characterization of the hundreds of types and subtypes of cells in the ...
In humans and other vertebrates, the pharyngeal arches are derived from all three germ layers (the primary layers of cells that form during embryonic development). [2] Neural crest cells enter these arches where they contribute to features of the skull and facial skeleton such as bone and cartilage. [2]
The face and neck development of the human embryo refers to the development of the structures from the third to eighth week that give rise to the future head and neck.They consist of three layers, the ectoderm, mesoderm and endoderm, which form the mesenchyme (derived form the lateral plate mesoderm and paraxial mesoderm), neural crest and neural placodes (from the ectoderm). [1]
For example, the expression of N-cadherin is crucial to maintaining separation of precursor neural cells from precursor epithelial cells. [2] Likewise, while the surface ectoderm becomes the epidermis , [ 6 ] the neuroectoderm is induced along the neural pathway by the notochord , which is typically positioned above it.
Cells from both the mesodermal and the ectodermal tissues contribute to the formation of the eye. Specifically, the eye is derived from the neuroepithelium, surface ectoderm, and the extracellular mesenchyme which consists of both the neural crest and mesoderm. [2] [3] [4] Neuroepithelium forms the retina, ciliary body, iris, and optic nerves.
The neural crest cells that are found outside of a given neuromere will express the same proteins as the cells that are found inside the neural tube. [1] The genes that are being expressed fall into two categories, extracellular signaling proteins and intracellular transcription factors. [ 1 ]