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Exosome-mediated delivery of superoxide dismutase extends life-span in Caenorhabditis elegans, apparently by reducing the level of reactive oxygen species. [90] Thus this system is being studied for its anti-aging potential. [90] This delivery system also improved survival under conditions of oxidative stress and heat. [90]
Exosomes are vesicular structures containing genetic information. Recently, exosomes are being utilized as drug carriers. These systems are observed to be stable, specific, and safe. Moreover, delivery of exosomes shows less immunogenic affects. Further surface modifications and conjugation with liposomes enhances the therapeutic effects.
Drug delivery systems have been around for many years, but there are a few recent applications of drug delivery that warrant 1. Drug delivery to the brain: Many drugs can be harmful when administered systemically; the brain is very sensitive to medications and can easily cause damage if a drug is administered directly into the bloodstream.
Exosomes are formed by invagination within a cell to create an intracellular vesicle called an endosome, or an endocytic vesicle. In general, exosomes are formed by segregating the cargo (e.g., lipids, proteins, and nucleic acids) within the endosome. Once formed, the endosome combines with a structure known as a multivesicular body (MVB). The ...
Another example of exosome-based sonodynamic therapy was illustrated by Liu et al. In this study, exosomes were decorated with porphyrin sensitizers and this system was used with an external ultrasound device to control and target drug delivery through SDT. [40]
Furthermore, effective intracellular delivery could expand the repertoire of usable protein drugs as most current protein-based therapeutics hit extracellular targets and this is a frontier of current research efforts. [27] Delivery of purified proteins into cells began as early as the 1960s.
The immune system and the neurological system, ... Exosomes, macrovesicles, and ... This means that the injury site needs to be accessed by surgery or drug delivery ...
Her research is focused on engineered live biotherapeutics, exosomes and lipid based drug delivery systems. [5] She was awarded a National Science Foundation CAREER award in 2018 for her work as well as over $18M from the NIH and other funding sources.
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