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The main efficacy measurement was the time to death from cardiovascular causes or need to be hospitalized for heart failure. [33] Of the individuals who received empagliflozin for an average of about two years, 14% died from cardiovascular causes or were hospitalized for heart failure, compared to 17% of the participants who received the ...
Subjects undergo a series of five 20-minute sleeping opportunities with an absence of alerting factors at 2-hour intervals on one day. The test is based on the idea that the sleepier people are, the faster they will fall asleep. [15] [16] The Maintenance of Wakefulness Test (MWT) is also used to quantitatively assess daytime sleepiness. This ...
Sotagliflozin (Inpefa) is a dual SGLT1/SGLT2 inhibitor approved by the US Food and Drug Administration (FDA) in May 2023, to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes, chronic kidney disease, and other cardiovascular risk factors.
In a statement on Friday, the two partners said Jardiance cut the risk of kidney disease progression and cardiovascular death by 28%, citing results from a late-stage trial which included people ...
When a person struggles to fall asleep or stay asleep without any obvious cause, it is referred to as insomnia, [2] which is the most common sleep disorder. [3] Other sleep disorders include sleep apnea , narcolepsy , hypersomnia (excessive sleepiness at inappropriate times), sleeping sickness (disruption of the sleep cycle due to infection ...
It has distinct meanings and causes. It can refer to the usual state preceding falling asleep, [1] the condition of being in a drowsy state due to circadian rhythm disorders, or a symptom of other health problems. It can be accompanied by lethargy, weakness and lack of mental agility. [2]
Sleep inversion may be a symptom of elevated blood ammonia levels [2] and is often an early symptom of hepatic encephalopathy. [3] Sleep inversion is a feature of African trypanosomiasis, after which the disease takes its common name, "African sleeping sickness"; [4] sleep-wake cycle disturbances are the most common indication that the disease has reached the stage where infection spreads into ...
A circadian rhythm is an entrainable, endogenous, biological activity that has a period of roughly twenty-four hours. This internal time-keeping mechanism is centralized in the suprachiasmatic nucleus (SCN) of humans, and allows for the internal physiological mechanisms underlying sleep and alertness to become synchronized to external environmental cues, like the light-dark cycle. [4]
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