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Maternal serum AFP (MSAFP) varies by orders of magnitude during the course of a normal pregnancy. MSAFP increases rapidly until about 32 weeks gestation, then decreases gradually. After the pregnancy ends it decreases rapidly, with a half-life of about 5 days. Typically, MSAFP is measured in the beginning of the second trimester (14–16 weeks).
The most common abnormality the test can screen is trisomy 21 (Down syndrome).In addition to Down syndrome, the triple and quadruple screens assess risk for fetal trisomy 18 also known as Edwards syndrome, open neural tube defects, and may also detect an increased risk of Turner syndrome, triploidy, trisomy 16 mosaicism, fetal death, Smith–Lemli–Opitz syndrome, and steroid sulfatase ...
174 11576 Ensembl ENSG00000081051 ENSMUSG00000054932 UniProt P02771 P02772 RefSeq (mRNA) NM_001134 NM_001354717 NM_007423 RefSeq (protein) NP_001125 NP_001341646 NP_031449 Location (UCSC) Chr 4: 73.43 – 73.46 Mb Chr 5: 90.64 – 90.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alpha-fetoprotein (AFP, α-fetoprotein ; also sometimes called alpha-1-fetoprotein, alpha ...
A multiple of the median (MoM) is a measure of how far an individual test result deviates from the median.MoM is commonly used to report the results of medical screening tests, particularly where the results of the individual tests are highly variable.
MSAFP/quad. screen (four simultaneous blood tests) (maternal serum AFP, inhibin A, estriol, and βHCG) – elevations, low numbers or odd patterns correlate with neural tube defect risk and increased risks of trisomy 18 or trisomy 21 [17] Ultrasound either abdominal or transvaginal to assess cervix, placenta, fluid and baby [18]
Percutaneous umbilical cord blood sampling (PUBS), also called cordocentesis, fetal blood sampling, or umbilical vein sampling is a diagnostic genetic test that examines blood from the fetal umbilical cord to detect fetal abnormalities. [1]
Rapid Interpretation of EKG's is a best-selling textbook for over 30 years [1] that teaches the basics of interpreting electrocardiograms. It adopts a simplistic fill-in-the-blank style [ 2 ] and is suited for medical students and junior residents. [ 1 ]
Reading Law: The Interpretation of Legal Texts is a 2012 book by United States Supreme Court Justice Antonin Scalia and lexicographer Bryan A. Garner.Following a foreword written by Frank Easterbrook, then Chief Judge of the US Court of Appeals for the Seventh Circuit, Scalia and Garner present textualist principles and canons applicable to the analysis of all legal texts, following by ...