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  2. Hypophosphatasia - Wikipedia

    en.wikipedia.org/wiki/Hypophosphatasia

    Enzyme replacement therapy with normal, or ALP-rich serum from patients with Paget's bone disease, was not beneficial. [50] [51] Phase 2 clinical trials of bone targeted enzyme-replacement therapy for the treatment of hypophosphatasia in infants and juveniles have been completed, and a phase 2 study in adults is ongoing. [52] [53]

  3. Bone health - Wikipedia

    en.wikipedia.org/wiki/Bone_health

    Optimal bone health is characterized by adequate bone mineral density (BMD) and proper bone microarchitecture, which together contribute to bone strength. [2] Osteoporosis, a skeletal disorder characterized by compromised bone strength and increased risk of fractures, is a major concern in bone health, particularly among older adults.

  4. Osteoporosis - Wikipedia

    en.wikipedia.org/wiki/Osteoporosis

    Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly . [ 3 ]

  5. Osteomalacia - Wikipedia

    en.wikipedia.org/wiki/Osteomalacia

    Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. The impairment of bone metabolism causes inadequate bone mineralization.

  6. Demineralization (physiology) - Wikipedia

    en.wikipedia.org/wiki/Demineralization_(physiology)

    Demineralization is the opposite process of mineralization; it is a process of reduction in the mineral content in tissue or an organism. Examples include bone demineralization or tooth demineralization. Demineralization can lead to serious diseases such as osteoporosis, rickets, or tooth decay. [1]

  7. Intraosseous infusion - Wikipedia

    en.wikipedia.org/wiki/Intraosseous_infusion

    A trigger allows for the IO needle to enter the bone marrow space at a preset length without any pressure being applied. [16] In the United States, the FDA has approved the use of the EZ-IO device in the proximal tibia and the head of the humerus. [16] Spring-Loaded: the Bone Injection Gun (BIG) and the Pyng Medical Corporation FAST 1

  8. Demineralized bone matrix - Wikipedia

    en.wikipedia.org/wiki/Demineralized_bone_matrix

    Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic "collagen" matrix. It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone morphogenetic proteins . [ 1 ]

  9. Renal osteodystrophy - Wikipedia

    en.wikipedia.org/wiki/Renal_osteodystrophy

    To confirm the diagnosis, renal osteodystrophy must be characterized by determining bone turnover, mineralization, and volume (TMV system) [2] (bone biopsy). [16] All forms of renal osteodystrophy should also be distinguished from other bone diseases which may equally result in decreased bone density (related or unrelated to CKD): osteoporosis [19]

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