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Those with long-term problems are at risk of urinary tract infections. [1] Causes include blockage of the urethra, nerve problems, certain medications, and weak bladder muscles. [1] Blockage can be caused by benign prostatic hyperplasia (BPH), urethral strictures, bladder stones, a cystocele, constipation, or tumors. [1]
A diary to track problems can help determine whether treatments are working. [3] Overactive bladder is estimated to occur in 7–27% of men and 9–43% of women. [1] It becomes more common with age. [1] Some studies suggest that the condition is more common in women, especially when associated with loss of bladder control. [1]
However, bladder problems are most prevalent among older women. [80] Women over the age of 60 years are twice as likely as men to experience incontinence; one in three women over the age of 60 years are estimated to have bladder control problems. [74] One reason why women are more affected is the weakening of pelvic floor muscles by pregnancy. [81]
An overactive bladder can result from hormonal issues, too, such as genitourinary syndrome of menopause, Kim said, which is a collection of symptoms caused by decreased estrogen levels ...
Alpha-adrenergic agonists may cause urinary retention by stimulating the contraction of the urethral sphincter. Calcium channel blockers may decrease the contractility of the smooth muscle tissue in the urinary bladder, causing urinary retention with overflow incontinence. Epidural anesthesia and delivery also can cause the overflow incontinence.
But some research has noted rare but serious side effects of once-weekly, 2.4-milligram (mg) semaglutide injections, such as pancreatitis, acute kidney injury, gallbladder issues, and thyroid cancer.
Some drugs need to be used with caution in patients with renal dysfunction. The use of nitrofurantoin is contraindicated in patients with an estimated GFR of less than 30 mL/min/1.73m 2 as drug accumulation can lead to increased side effects and impaired recovery of the urinary tract, increasing the risk of treatment failure. [29]
Among women with chronic pelvic pain, the most common comorbidities are endometriosis (70%), postpartum pelvic pain (44%), bladder pain syndrome (61%) and irritable bowel syndrome (39%).
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