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Bamlanivimab and etesevimab, administered together, are authorized in the United States for the treatment of mild-to-moderate COVID-19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) with positive results of direct SARS-CoV-2 viral testing, and who are at high risk for progression to severe COVID-19 ...
On 9 November 2020, bamlanivimab was granted an emergency use authorization by the US Food and Drug Administration (FDA) for the treatment of mild-to-moderate COVID-19 in adults and adolescents. Bamlanivimab is authorized for people with positive results of direct SARS-CoV-2 viral testing who are twelve years of age and older weighing at least ...
In January 2021, the United States agreed to purchase 1.25 million doses of the drug for $2.625 billion, at $2,100 per dose. [29] [30] On 14 September, another 1.4 million doses were purchased for the same price, totaling $2.94 billion. [31] In January 2021, the German government purchased 200,000 doses for €400 million at €2,000 per dose. [32]
Vaccine combinations (few exceptions), antibiotics, low-dose steroids (less than 20 mg per day), minor infections with low fever (below 38.5º Celsius), diarrhea, malnutrition, kidney or liver disease, heart or lung disease, non-progressive encephalopathy, well controlled epilepsy or advanced age, are not contraindications to vaccination.
The vaccine consists of a version of the receptor binding domain (RBD) of the SARS‑CoV‑2 spike protein, together with the adjuvants aluminium hydroxide gel and CpG 1018. [2] As the RBD protein is poorly immunogenic alone, adjuvantation is essential for a RBD-based vaccine immunogenicity. [ 9 ]
In October 2022, a Hong Kong study found that two doses of CoronaVac provided protection of only 64% to 75% for older adults. However, an extra booster or a third dose of CoronaVac was able to raise the level of protection against COVID-19 to about 98%. [45] In January 2024, Sinovac confirmed that it had discontinued production of CoronaVac. [46]
The GSK adjuvant is intended to enhance the immune response to CoVLP, reducing the amount of antigen required per dose, thereby facilitating mass production of vaccine doses. [ 18 ] [ 19 ] In March 2022, the vaccine was rejected by the World Health Organization due to the tobacco company Philip Morris International owning a stake in Medicago ...
Vilobelimab, sold under the brand name Gohibic, is a monoclonal antibody that is used for the treatment of COVID-19. [1] [2] [4] It is a human-mouse chimeric IgG4 kappa antibody that targets human C5a in plasma.