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In August 2020, the U.S. Food and Drug Administration (FDA) became aware of nitrosamine impurities in certain samples of rifampin. [61] The FDA and manufacturers are investigating the origin of these impurities in rifampin, and the agency is developing testing methods for regulators and industry to detect the 1-methyl-4-nitrosopiperazine (MNP ...
Food and industrial bioproducts and bioprocessing. Chichester, West Sussex, UK Hoboken: Wiley-Blackwell. ISBN 978-0-8138-2105-4. OCLC 784124288. González, Mónica (2020). Advances in food bioproducts and bioprocessing technologies. Boca Raton, FL: CRC Press, Taylor & Francis Group. ISBN 978-1-000-68293-9. OCLC 1104922947.
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
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A biopharmaceutical, also known as a biological medical product, [1] or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.
Bioproducts engineers also develop energy efficient, environmentally friendly manufacturing processes for these products as well as effective end-use applications. Bioproducts engineers play a critical role in a sustainable 21st century bio-economy by using renewable resources to design, develop, and manufacture the products we use every day.
Scientists at the Italian drug company Achifar discovered rifabutin in 1975. (Eventually Archifar became part of Farmitalia Carlo Erba, a unit of the conglomerate Montedison which was subsequently bought by Pharmacia) This company's Adria Laboratories subsidiary filed for Food and Drug Administration (FDA) approval of rifabutin under the brand name Mycobutin in the early 1990s and the drug ...
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