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Pyrantel is a medication used to treat a number of parasitic worm infections. [2] This includes ascariasis , hookworm infections , enterobiasis (pinworm infection), trichostrongyliasis , and trichinellosis . [ 2 ]
If used by itself it causes the worm to be passed out in the feces. Dosage is 75 mg/kg (max 3.5 g) as a single oral dose. [citation needed] Pyrantel pamoate (Antiminth, Pin-Rid, Pin-X), depolarizes ganglionic block of nicotinic neuromuscular transmission, resulting in spastic paralysis of the worm. Spastic (tetanic) paralyzing agents, in ...
Praziquantel and its metabolites are mainly excreted renally; within 24 h after a single oral dose, 70 to 80% is found in urine, but less than 0.1% as the unchanged drug. Praziquantel is metabolized through the cytochrome P450 pathway via CYP3A4 .
In the article, it says: "Dosage is 11 mg/kg not to exceed 1 g as a single dose." Does this mean 11mg of pyrantel embonate or 11mg of pure pyrantel? In the package insert of a German pyrantel drug ("Helmex"), it says dosage is 10mg/kg, with one tablet containing 720mg of pyrantel embonate equivalent to 250mg of pure pyrantel.
Those recommended by the World Health Organization for ascariasis are: albendazole, mebendazole, levamisole and pyrantel pamoate. [2] Single-dose of albendazole, mebendazole, and ivermectin are effective against ascariasis. They are effective at removing parasites and eggs from the intestines. [34]
Treatment is typically with two doses of the medications mebendazole, pyrantel pamoate, or albendazole two weeks apart. [4] Everyone who lives with or takes care of an infected person should be treated at the same time. [1] Washing personal items in hot water after each dose of medication is recommended. [1]
A schistosomicide is a drug used to combat schistosomiasis. [1] List. Examples listed in MeSH include: [2] amoscanate; arteether; artemether; chloroxylenol; hycanthone;
The typical Pyrantel pamoate (pyrantel salts) dose of 6.6 mg per kilogram. [2] At this dose, the treatment is anywhere between 80-87% effective. [3] Doubling this dose only increases the overall efficacy to 93-95%. [2] [3] Praziquantel at a dose of 1 mg per kg is 89-100% effective at eliminating an infection of Anoplocephala perfoliata. [2]
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