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Leukocyte adhesion deficiency (LAD) is a genetic disease associated with a defect in the leukocyte extravasation process, caused by a defective integrin β2 chain (found in LFA-1 and Mac-1). This impairs the ability of the leukocytes to stop and undergo diapedesis. People with LAD suffer from recurrent bacterial infections and impaired wound ...
The best-characterized ligand for the three selectins is P-selectin glycoprotein ligand-1 , which is a mucin-type glycoprotein expressed on all white blood cells. Neutrophils and eosinophils bind to E-selectin. One of the reported ligands for E-selectin is the sialylated Lewis X antigen (SLe x). Eosinophils, like neutrophils, use sialylated ...
In cellular biology, angiopellosis (cell extravasation) is the movement of cells out of the circulatory system, into the surrounding tissue.This process is specific to non-leukocytic cells; white blood cells (leukocytes) employ diapedesis for movement out of circulation.
Extravasation of irrigation fluid is the unintended migration of irrigation fluid (e.g., saline) introduced into a human body.This may occur in several types of endoscopic surgery, such as minimally invasive orthopedic surgery, i.e., arthroscopy, TURP (trans-urethral resection of the prostate), and TCRE (trans-cervical resection of the endometrium).
The process of leukocyte movement from the blood to the tissues through the blood vessels is known as extravasation and can be broadly divided up into a number of steps: Leukocyte margination and endothelial adhesion: The white blood cells within the vessels which are generally centrally located move peripherally towards the walls of the ...
During leukocyte extravasation, white blood cells move in response to cytokines from the blood into diseased or infected tissues, usually in the direction of a chemical gradient, [1] in a process called chemotaxis. The presence of lymphocytes in tissue in greater than normal numbers is likewise called infiltration.
The Inner Life of the Cell is an 8.5-minute 3D computer graphics animation illustrating the molecular mechanisms that occur when a white blood cell in the blood vessels of the human body is activated by inflammation (Leukocyte extravasation).
ICAM-1 is a ligand for LFA-1 , a receptor found on leukocytes. [9] When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. [10] LFA-1 has also been found in a soluble form, [11] which seems to bind and block ICAM-1. [12]