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Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2] It is absent in bullous pemphigoid , making it useful for differential diagnosis .
Histopathological image of dyshidrotic dermatitis, showing focal spongiotic change in the epidermis. Spongiosis is mainly intercellular [1] edema (abnormal accumulation of fluid) in the epidermis, [2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification. [3]
Variable degree of epidermal spongiosis and vesicle formation, filled with proteinaceous fluid containing lymphocytes and histiocytes. Usually superficial dermal edema with perivascular lymphocytic infiltrate, with exocytosis. No acanthosis or parakeratosis. Typical findings: [2] Mild to moderate spongiosis and exocytosis of inflammatory cells
The Joint Commission began setting standards for pain assessment in 2001 stating that the route of analgesic administration dictates the times for pain reassessment, as different routes require different amounts of time for the medication to have a therapeutic effect. Oral: 45–69 minutes. Intramuscular: 30 minutes.
Note the intercellular IgG deposits in the epidermis and the early intraepidermal vesicle caused by acantholysis. Pemphigus (/ ˈ p ɛ m f ɪ ɡ ə s / or / p ɛ m ˈ f aɪ ɡ ə s /) is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. [1] The name is derived from the Greek root pemphix, meaning "blister ...
A patient's self-reported pain is so critical in the pain assessment method that it has been described as the "most valid measure" of pain. [ 2 ] [ 3 ] The focus on patient report of pain is an essential aspect of any pain scale, but there are additional features that should be included in a pain scale.
Where is the pain? Or the maximal site of the pain. O Onset When did the pain start, and was it sudden or gradual? Include also whether it is progressive or regressive. C Character What is the pain like? An ache? Stabbing? R Radiation: Does the pain radiate anywhere? A Associations Any other signs or symptoms associated with the pain? T Time course
Perinuclear vacuolization of epidermal keratinocytes (one indicated by arrows), in this case an insignificant incidental finding. Subnuclear vacuolization in palisading cell - vacuoles at the basement membrane aspect, resembling a brighter stripe in the periphery of palisades.