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A dendritic cell (DC) is an antigen-presenting cell (also known as an accessory cell) of the mammalian immune system.A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system.
T cells become activated by recognising foreign antigens bound to antigen presenting cells (APC), in particular, dendritic cells. [5] In order for naïve T cells to bind to their specific antigen, they need to experience physical contact with those cells. Since antigen levels are usually low, contact in blood circulation would be unlikely.
A dendritic cell. Dendritic cells are specialized antigen-presenting cells that have long outgrowths called dendrites, [87] that help to engulf microbes and other invaders. [88] [89] Dendritic cells are present in the tissues that are in contact with the external environment, mainly the skin, the inner lining of the nose, the lungs, the stomach ...
Here the T-cells mainly interact with dendritic cells, and the reticular network is dense. [18] The medulla contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells. There are fewer cells in the medulla. [5] The medullary cords are cords of lymphatic tissue, and include plasma cells, macrophages ...
Due to this interaction, dendritic cells move to the T cell zone or to the B cell follicle along the fibroblast reticular cell network. [4] Dendritic cells exhibit C-type lectin receptors , which bind to gp38 on the surface of lymphatic endothelial cells. Lymphocytes leave the lymph node, as effector immune cells, via the efferent lymph vessels.
Cellular extensions of certain mural cells possess the capability to regulate the diameter of their associated blood vessels. Through the processes of vasoconstriction and vasodilation, these cells can actively control the rate of blood flow by means of:
Dendritic cells are named after their structure that resembles that of a dendrite of an axon, and they have two vital functions: display antigens, which are recognized by T cells and alert lymphocytes of the presence of an injury or infection. When the body is introduced to infection or injury, dendritic cells migrate to immune or lymphoid ...
The LT-αβ complexes are the primary ligands for the lymphotoxin beta receptor (LTβR), which is expressed on tissue cells in multiple lymphoid organs, as well as on monocytes and dendritic cells. [ 3 ] [ 5 ] The soluble LT-α homotrimer binds to TNF receptors 1 and 2 (TNFR-1 and TNFR-2), and the herpesvirus entry mediator , expressed on T ...
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