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Cancer of the stomach, also called gastric cancer, is the fourth-most-common type of cancer and the second-highest cause of cancer death globally. [2] Eastern Asia (China, Japan, Korea, Mongolia) is a high-risk area for gastric cancer, and North America, Australia, New Zealand and western and northern Africa are areas with low risk. [5]
In 2012, stomach cancer was the fifth most-common cancer with 952,000 cases diagnosed. [16] It is more common both in men and in developing countries. [ 97 ] [ 98 ] In 2012, it represented 8.5% of cancer cases in men, making it the fourth most-common cancer in men. [ 99 ]
GISTs are most common in individuals ranging in age from 40 years old to 70 years old and are rare in small children and young adults. [2] Individuals with these tumors may experience swelling in the abdomen , pain, vomiting , nausea , appetite loss, weight loss , low blood cell counts, gastrointestinal bleeding (which can result in bloody or ...
Colorectal cancers are the third most common cancer diagnosed in men and women in the United States, according to the American Cancer Society, which estimates that more than 95,500 cases of colon ...
The signs and symptoms of colorectal cancer depend on the location of the tumor in the bowel, and whether it has spread elsewhere in the body ().The classic warning signs include: worsening constipation, blood in the stool, decrease in stool caliber (thickness), loss of appetite, loss of weight, and nausea or vomiting in someone over 50 years old. [15]
Globally, pancreatic cancer is the 11th most-common cancer in women and the 12th most-common in men. [10] The majority of recorded cases occur in developed countries . [ 10 ] People from the United States have an average lifetime risk of about 1 in 67 (or 1.5%) of developing the disease, [ 114 ] slightly higher than the figure for the UK. [ 115 ]
Cancers of the GI tract (esophageal, gastric, and colorectal) are on the rise. Over the last 30 years there has been an increase in incidence of adenocarcinoma of the esophagus, gastroesophageal junction, and gastric cardia. [3] Gastric cancer is the fourth most common malignant tumor and third most common cause of cancer related death.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. [2] They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%), [2] PDGFRA gene (10%), [2] or BRAF kinase (rare).
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