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A cell that has been treated with taxol and had a catastrophic mitosis. The cell has become multinucleated after an unsuccessful mitosis. Mitotic catastrophe has been defined as either a cellular mechanism to prevent potentially cancerous cells from proliferating or as a mode of cellular death that occurs following improper cell cycle progression or entrance.
HAP1 cells are malignant neoplastic cells, also known as cancer cells.These cells are characterized primarily by uninhibited growth. [7] As the rate of mitosis increases, defects in the nuclear spindles form, which results in atypical chromosomes, such as those found in HAP1 cells.
The function or significance of mitosis, is the maintenance of the chromosomal set; each formed cell receives chromosomes that are alike in composition and equal in number to the chromosomes of the parent cell. Mitosis occurs in the following circumstances: Development and growth: The number of cells within an organism increases by mitosis.
Cancer cells are cells that divide continually, forming solid tumors or flooding the blood or lymph with abnormal cells. [1] Cell division is a normal process used by the body for growth and repair. A parent cell divides to form two daughter cells, and these daughter cells are used to build new tissue or to replace cells that have died because ...
Binucleated cells are most easily identified by viewing tubulin, which surrounds the two nuclei in the cell. Binucleated cells may be mistaken for two cells in close proximity when viewing only nuclei. The binucleated cell above is an oral squamous cell carcinoma, cell line UPCI-SCC-103. A: The cancer cell treated with antibodies against tubulin.
Cancer cells may lose their dependence on external mitogens by a variety of pathways. First, cancer cells can produce their own mitogens, a term called autocrine stimulation. [ 5 ] This can result in a deadly positive feedback loop - tumor cells produce their own mitogens, which stimulate more tumor cells to replicate, which can then produce ...
Mitotic nondisjunction results in somatic mosaicism, since only daughter cells originating from the cell where the nondisjunction event has occurred will have an abnormal number of chromosomes. [3] Nondisjunction during mitosis can contribute to the development of some forms of cancer, e.g., retinoblastoma (see below). [7]
Cancer is defined by uncontrolled cell growth and malignant cells can undergo cell division with multipolar spindles because they can group multiple centrosomes into two spindles. These multipolar spindles are often assembled early in mitosis and rarely seen towards the later stages.