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Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1] Over time affected skin may become darker, stiffen, peel, or bleed. [1] [3]
Deficiency causes pellagra, a reversible nutritional wasting disease characterized by four classic symptoms often referred to as the four Ds: diarrhea, dermatitis, dementia, and death. The dermatitis occurs on areas of skin exposed to sunlight, such as backs of hands and neck.
A disease that was characterized by dermatitis of sunlight-exposed skin was described in Spain in 1735 by Gaspar Casal. He attributed the cause to poor diet. [52] In northern Italy it was named pellagra from the Lombard language (agra = holly-like or serum-like; pell = skin). [53] [54] In time, the disease was more closely linked specifically ...
Adults ages 65 and older may be at a higher risk of a vitamin B deficiency, the experts say. "Sometimes older people have a harder time metabolizing food, so they might benefit from a supplement ...
“B12 deficiency is also more common in people with Alzheimer’s disease, so you may have two things going on,” Kaiser says. As a result, doctors will usually recommend taking a vitamin B12 ...
Micronutrient deficiencies are considered a public health problem worldwide. For over 30 years it has been estimated that more than two billion people of all ages are affected by this burden, [1] while a recently published study based on individual-level biomarker data estimated that there are 372 million children aged 5 years and younger, and 1.2 billion non-pregnant women of reproductive age ...
"Normal" levels of vitamin B12 may not be enough to ward off dementia, new research finds.. Researchers at University of California San Francisco studied 231 healthy older adults (averaging 71 ...
[85] It was also referred to as "vitamin PP", "vitamin P-P" and "PP-factor", all derived from the term "pellagra-preventive factor". [86] In the late 1930s, studies by Tom Douglas Spies, Marion Blankenhorn, and Clark Cooper confirmed that nicotinic acid cured pellagra in humans. [87] The prevalence of the disease was greatly reduced as a result ...