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Phentermine, also known as α,α-dimethylphenethylamine or as α-methylamphetamine, is a substituted phenethylamine and amphetamine. [ 51 ] [ 52 ] [ 53 ] It is the derivative of amphetamine in which a second methyl group is present at the alpha carbon .
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
In 1959, phentermine had been FDA approved and fenfluramine in 1973. In the early 1990s two studies found that a combination of the drugs was more effective than either on its own; fen-phen became popular in the United States and had more than 18 million prescriptions in 1996. [ 40 ]
By mid-2017, Mount Carmel East had announced plans to build a new $26 million, 80-bed, behavioral-health hospital near the Mount Carmel East campus, to be opened by fall 2018. Inpatient behavioral-health beds at Mount Carmel West hospital would be moved there upon closure of West's behavioral-health facility.
OhioHealth Doctors Hospital is a 213-bed tertiary care teaching hospital located in Columbus in the U.S. state of Ohio. Doctors Hospital operates the second largest osteopathic medical training program in the United States. Each year, the hospital trains 160 physicians in residencies and fellowships.
Chemically, it is a substituted phenethylamine and amphetamine and is closely related to phentermine and methamphetamine. [4] [9] [1] Mephentermine was first described and introduced for medical use by 1952. [10] It was discontinued in the United States between 2000 and 2004. [2] [7] The medication appears to remain available only in India.
The New York Psychiatric Institute, associated with Columbia University, the Research Foundation of the City University of New York, and Mount Sinai Medical Center tested fenfluramine intravenously on more than 100 Black and Hispanic boys between the ages of 6 and 10, with delinquent older brothers, to test the theory that delinquent behavior could be predicted by serotonin levels.
Fen-phen (popular combination of fenfluramine and phentermine) 1997 Cardiotoxicity Fenclofenac: 1984 UK Cutaneous reactions; animal carcinogenicity. [3] Fenclozic acid: 1970 UK, US Hepatotoxicity. [3] Fenfluramine: 1997 European Union, UK, US, India, South Africa, others