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Cotinine is an alkaloid found in tobacco [1] and is also the predominant metabolite of nicotine, [2] [3] typically used as a biomarker for exposure to tobacco smoke. Cotinine is currently being studied as a treatment for depression, post-traumatic stress disorder (PTSD), schizophrenia, Alzheimer's disease and Parkinson's disease.
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound.It is classified as a tetrahydropyridine.It is of interest as a precursor to the monoaminergic neurotoxin MPP +, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain.
As of 2022, no disease-modifying drugs (drugs that target the causes or damage) are approved for Parkinson's, so this is a major focus of Parkinson's research. [ 262 ] [ 263 ] Active research directions include the search for new animal models of the disease and studies of the potential usefulness of gene therapy , stem cell transplants, and ...
Researchers have found that people who take a type of type 2 diabetes drugs SGLT2 inhibitors have a significantly lower risk of dementia, overall, and of Alzheimer's disease and Parkinson's, in ...
In August 2024, the B.C. (British Columbia) Supreme Court certified a class-action lawsuit against Syngenta on behalf of at least two plaintiffs who were diagnosed with Parkinson's after exposure to paraquat. [69] According to the NIEHS, pesticide exposure has consistently been associated with the onset of Parkinson's disease. [70]
This is an accepted version of this page This is the latest accepted revision, reviewed on 9 December 2024. Circumstances, mechanisms, and factors of tobacco consumption on human health "Health effects of smoking" and "Dangers of smoking" redirect here. For cannabis, see Effects of cannabis. For smoking crack cocaine, see Crack cocaine § Health issues. "Smoking and health" redirects here. For ...
Exposure to pesticides, metals, solvents, and other toxicants has been studied as a factor in the development of Parkinson's disease. [7] No definitive causal relationship has yet been established. Recent studies also reveal that individuals that sustain mild head injuries (concussions) also have an increased risk of acquiring the disease.
Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease, affects 1% of people over 60 years of age. [1] [2] [3] In the past three decades, the number of PD cases has doubled globally from 2.5 million in 1990 to 6.1 million in 2016. [4] [5] As of 2022, there are ~10 million PD cases globally. [6]
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