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Mazindol is used in short-term (i.e., a few weeks) treatment of obesity, in combination with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in people with a body mass index greater than 30, or in those with a body mass index greater than 27 in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia.
Originally available only by prescription, it was approved by the FDA for over-the-counter sale in February 2007. [32] In May 2010, the U.S. Food and Drug Administration (FDA) approved a revised label for Xenical to include new safety information about rare cases of severe liver injury that have been reported with the use of this medication. [33]
In the mid-1990s the US FDA approved dexfenfluramine as a weight loss drug. After several reports of adverse cardiovascular effects, the FDA banned dexfenfluramine in 1997. [12] [17] [18] It appears that the 5-HT 2B receptors, expressed in cardiac valves, are responsible for the valvulopathies reported from the use of fenfluramine and ...
Ozempic—designed and approved to help people manage type 2 diabetes symptoms—has not formally been approved for use as a weight loss medicine, but has been hailed a “miracle” intervention ...
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