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In the mammalian kidney, the regeneration of the tubular component following an acute injury is well known. Recently regeneration of the glomerulus has also been documented. Following an acute injury, the proximal tubule is damaged more, and the injured epithelial cells slough off the basement membrane of the nephron.
Multipotent mouse kidney progenitor cells (MKPC) were obtained from Myh9 targeted mutant mice. Injection of MKPC into mice post-ischemic injury saw the MKPC regenerating different cell lineages and was able to regenerate renal function and enhanced survival. [7]
The potential for regeneration in mature kidneys is limited [37] [38] because new nephrons cannot be formed. [39] But in cases of limited injury, renal function can be restored through compensatory mechanisms. [40] The kidneys can have noninfectious and infectious diseases; in rare cases, congenital and hereditary anomalies occur in the kidneys ...
Unlike mammals, the kidneys of reptiles do not have a clear distinction between cortex and medulla. [43] The kidneys lack the loop of Henle, have fewer nephrons (from about 3,000 to 30,000), and cannot produce hypertonic urine. [3] [21] Nitrogenous waste products excreted by the kidneys may include uric acid, urea and ammonia. [55]
Size of a normal pig kidney (left) compared to a solitary pig kidney (right). Compensatory growth is a type of regenerative growth that can take place in a number of human organs after the organs are either damaged, removed, or cease to function. [1] Additionally, increased functional demand can also stimulate this growth in tissues and organs. [2]
Additional complications presented themselves after the first surgery, team doctor Dragan Radovanovic said, requiring the second procedure on Sunday where the kidney was removed.
This illustration demonstrates the normal kidney physiology, including the Proximal Convoluted Tubule (PCT), Loop of Henle, and Distal Convoluted Tubule (DCT). It also includes illustrations showing where some types of diuretics act, and what they do. Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney.
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