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Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
The 'Nuts and Bolts' of Phage Therapy. a special issue of the journal, Current Pharmaceutical Biotechnology, consisting of six articles on phage therapy, plus an editorial. Carnazza, S., Guglielmino, S. eds. 2010. Phage Display As a Tool for Synthetic Biology. Nova Science Publishers, Hauppauge, New York. ISBN 978-1-60876-987-2, Google Books
Phage therapy is the method by which bacteriophages (viruses which infect bacteria) are used to treat bacterial infections or reduce bacterial populations. Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy .
An example of a bacteriophage known to follow the lysogenic cycle and the lytic cycle is the phage lambda of E. coli. [53] Sometimes prophages may provide benefits to the host bacterium while they are dormant by adding new functions to the bacterial genome , in a phenomenon called lysogenic conversion .
Transmission electron micrograph of multiple bacteriophages attached to a bacterial cell wall. A phageome is a community of bacteriophages and their metagenomes localized in a particular environment, similar to a microbiome. [1] [2] Phageome is a subcategory of virome, which is all of the viruses that are associated with a host or environment. [3]
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
A more detailed account of the use of phage in major biological discoveries can be found on the page, bacteriophage. As one of the earliest applied microbiologists, d'Hérelle's microbe-centered worldview has been noted for its prescience, since microbes are playing increasingly important roles in bioremediation , microbial fuel cells , gene ...
Several laboratories have been testing suitability of bacteriophage isolates to control certain bacterial pathogens. Significant advancements in this research have been made at the Bacteriophage Institute in Tbilisi, Georgia, where phage therapy is routinely applied in medicine research. Today treatment of antibiotic resistant bacteria is a ...